Who was Malik Ambar and why was he significant?

He was a powerful prime minister of Ahmadnagar who successfully resisted Mughal expansion for decades using innovative guerrilla tactics and military management.

End of Ahmadnagar: Annexation by the Mughal Empire (2004 PYQ)

ID: MED_REG_2004_20 Ref: Satish Chandra, Medieval India

How did the dynasty of Nizam Shahi of Ahmadnagar come to an end?

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The Nizam Shahi dynasty of Ahmadnagar ended when the Mughal Empire annexed it under Shah Jahan in 1636. The last ruler, Hussain Shah, was captured and imprisoned for life in Gwalior Fort.